Research Articles

SOD1 is a synthetic-lethal target in PPM1D-mutant leukemia cells. Linda Zhang, Joanne I Hsu, Etienne D Braekeleer, Chun-Wei Chen, Tajhal D Patel, Alejandra G Martell, Anna G Guzman, Katharina Wohlan, Sarah M Waldvogel, Hidetaka Uryu, Ayala Tovy, Elsa Callen, Rebecca L Murdaugh, Rosemary Richard, Sandra Jansen, Lisenka Vissers, Bert BA de Vries, Andre Nussenzweig, Shixia Huang, Cristian Coarfa, Jamie Anastas, Koichi Takahashi, George Vassiliou, Margaret A Goodell. (2024) Elife. 18:12:RP91611. doi: 10.7554/eLife.91611.

Phase I Trial of GD2.CART Cells Augmented With Constitutive Interleukin-7 Receptor for Treatment of High-Grade Pediatric CNS Tumors. Frank Y Lin , Austin Stuckert, Candise Tat, Mark White, Lucia Ruggieri, Huimin Zhang, Birju Mehta, Natalia Lapteva, Zhuyong Mei, Angela Major, Sachin Thakkar, Thomas Shum, Kathan Parikh, Meng-Fen Wu, Holly B Lindsay, Lauren Scherer, Meghan Shekar, Patricia Baxter, Tao Wang, Bambi Grilley, Karen Moeller, John Hicks, Angshumoy Roy, Jamie Anastas, Fatema Malbari , Guillermo Aldave, Murali Chintagumpala , Susan Blaney, D Williams Parsons, Malcolm K Brenner, Helen E Heslop, Cliona M Rooney, Bilal Omer. (2024) Journal of Clinical Oncology. Aug 10;42(23):2769-2779. doi: 10.1200/JCO.23.02019.

BAF Complex Maintains Glioma Stem Cells in Pediatric H3K27M Glioma. Panditharatna E, Marques JG, Wang T, Trissal MC, Liu I, Jiang L, Beck A, Groves A, Dharia NV, Li D, Hoffman SE, Kugener G, Shaw ML, Mire HM, Hack OA, Dempster JM, Lareau C, Dai L, Sigua LH, Quezada MA, Stanton AJ, Wyatt M, Kalani Z, Goodale A, Vazquez F, Piccioni F, Doench JG, Root DE, Anastas JN, Jones KL, Conway AS, Stopka S, Regan MS, Liang Y, Seo HS, Song K, Bashyal P, Jerome WP, Mathewson ND, Dhe-Paganon S, Suvà ML, Carcaboso AM, Lavarino C, Mora J, Nguyen QD, Ligon KL, Shi Y, Agnihotri S, Agar NYR, Stegmaier K, Stiles CD, Monje M, Golub TR, Qi J, Filbin MG. (2022) Cancer Discovery. (12):2880-2905. doi: 10.1158/2159-8290.CD-21-1491.

RACK7 recognizes H3.3G34R mutation to suppress expression of MHC class II complex components and their delivery pathway in pediatric glioblastoma. Jiao, F., Li, Z., He, C., Xu, W., Yang, G., Liu, T, Shen, H., Cai, J., Anastas, J.N., Mao, Y., Yu, Y., Lan, F., Geno, Y., Jones, C., Xu, Y., Baker, S.J.*, Shi, Y.*, Guo, R.*. (2020) Science Advances. 17;6(29):eaba2113. doi: 10.1126/sciadv.aba2113.

Re-programing chromatin with a bifunctional LSD1/HDAC inhibitor induces therapeutic differentiation in DIPG. Anastas, J.N., Zee, B.M., Kalin, J.H., Kim, M., Guo, R., Alexandrescu, S., Blanco, M.A., Giera, S., Gillespie, S.M., Das, J., et al. (2019). Cancer Cell. 36(5), 528-544.

WNT5A enhances resistance of melanoma cells to targeted BRAF inhibitors. Anastas, J.N., Kulikauskas, R.M., Tamir, T., Rizos, H., Long, G.V., von Euw, E.M., Yang, P.-T., Chen, H.-W., Haydu, L., Toroni, R.A., et al. (2014). J. Clin. Invest. 124(7):2877-90.doi: 10.1172/JCI70156.

A protein complex of SCRIB, NOS1AP and VANGL1 regulates cell polarity and migration, and is associated with breast cancer progression. Anastas, J.N., Biechele, T.L., Robitaille, M., Muster, J., Allison, K.H., Angers, S., and Moon, R.T. (2011). Oncogene. 31(32):3696-708.

WLS inhibits melanoma cell proliferation through the β-catenin signalling pathway and induces spontaneous metastasis. Yang, P.T., Anastas, J.N., Toroni, R.A., Shinohara, M.M., Goodson, J.M., Bosserhoff, A.K., Chien, A.J., and Moon, R.T. (2012). EMBO Mol. Med. 4, 1294–1307.

Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/β-catenin signaling. Berndt, J.D., Aoyagi, A., Yang, P., Anastas, J.N., Tang, L., and Moon, R.T. (2011). J. Cell Biol. 194, 737–750.

New regulators of Wnt/beta-catenin signaling revealed by integrative molecular screening. Berndt, J.D., Aoyagi, A., Yang, P., Anastas, J.N., Tang, L., and Moon, R.T. (2011). J. Cell Biol. 194, 737–750.

Reviews and Perspectives

A road map for the treatment of pediatric diffuse midline glioma. Koschmann C., Al-Holou W.N., Alonso M.M., Anastas J.….Venneti S. et al. (2024) Cancer Cell. 8;42(1):1-5. doi: 10.1016/j.ccell.2023.11.002. Epub 2023 Nov 30.et al.

Applying single cell multi-omic analyses to understand treatment resistance in pediatric high grade glioma. Murdaugh, R.L., and Anastas, J.N. (2023). Frontiers in Pharmacology. 14: 1002296.

Histone Serotonylation: Can the Brain Have “Happy” Chromatin? Anastas, J.N., and Shi, Y. (2019). Molecular Cell. 74, 418–420.

Histone Lysine Demethylase Inhibitors. Jambhekar, A., Anastas, J.N., and Shi, Y. (2017). Cold Spring Harb. Perspect. Med. 7.

Functional crosstalk between WNT signaling and tyrosine kinase signaling in cancer. Anastas, J.N. (2016). Seminars in Oncology, Vol 42, No 6, December 2015, pp 820-831. Semin. Oncol. 43, 526.

WNT signalling pathways as therapeutic targets in cancer. Anastas, J.N., and Moon, R.T. (2013). Nat. Rev. Cancer 13, 11–26.